En el Annals se publica una revisión sistemática de los últimos 5 estudios para valorar el efecto del control glucémico intensivo sobre el riesgo cardiovascular (UKPDS,ADVANCE,ACCORD Y VATS). Adjunto los comentarios de los editores sobre el trabajo
Context
The relative benefits and harms of intensive versus conventional glucose control for type 2 diabetes are controversial.
Contribution
This review of 5 large trials found that, compared with conventional control, intensive glucose control reduced the risk for cardiovascular disease (mostly nonfatal myocardial infarction) but not for cardiovascular death or all-cause mortality, and increased risk for severe hypoglycemia. Trial design, achieved control, and findings were heterogeneous:
Early trials suggested possible decreased risk for death with intensive control, whereas some more recent trials suggested possible increased risk for death with more stringent control.
Caution
The investigators did not evaluate costs. They pooled summary findings from trials rather than individual data from patients.
No hay comentarios:
Publicar un comentario